There is security software like Avast, Kaspersky, BitDefender and ESET that intercept secure connection certificates and send their own.

https://support.mozilla.org/en-US/kb/firefox-cant-load-websites-other-browsers-can

https://support.mozilla.org/en-US/kb/firefox-and-other-browsers-cant-load-websites

https://support.mozilla.org/en-US/kb/secure-connection-failed-firefox-did-not-connect

https://support.mozilla.org/en-US/kb/websites-dont-load-troubleshoot-and-fix-errors

What do the security warning codes mean

Thank you, but I have gone through these, all before:

• No Proxy is Off
• There is no warning other than server cannot be reached
• I do not have Avast, Kaspersky, BitDefender and ESET
• I do have Sophos and it is turned off for testing this.
• Proxy to None
• network.dns.disableIPv6 is TRUE
• network.dns.disablePrefetch is TRUE
• network.dns.disablePrefetchFromHTTPS is TRUE

Did you check the links I posted?

Start Firefox using Troubleshoot(Safe) Mode {web link}

A small dialog should appear. Click Start In Troubleshoot(Safe) Mode (not Refresh). Is the problem still there?

Start your Computer in safe mode with network support. Then start Firefox. Try Secure websites. Is the problem still there?

Starting Any Computer In Safe Mode (web link) Free Online Encyclopedia

https://www.bleepingcomputer.com/tutorials/how-to-start-windows-in-safe-mode/

https://www.digitalcitizen.life/4-ways-boot-safe-mode-windows-10/ +++++++++++++++++++++++++++++++++++++++++++++++ If the problem goes away with the computer in Safe Mode, the problem is with one of the other programs on the system.

As a test, disable your protection programs.

You can try these steps in case of issues with webpages:

You can reload webpage(s) and bypass the cache to refresh possibly outdated or corrupted files.

• hold down the Shift key and left-click the Reload button
• press "Ctrl + F5" or press "Ctrl + Shift + R" (Windows,Linux)
• press "Command + Shift + R" (Mac)

Clear the Cache and remove the Cookies for websites that cause problems via the "3-bar" Firefox menu button (Settings).

"Remove the Cookies" for websites that cause problems:

• Settings -> Privacy & Security
  Cookies and Site Data: "Manage Data"

"Clear the Cache":

• Settings -> Privacy & Security
  Cookies and Site Data -> Clear Data -> [X] Cached Web Content -> Clear

Start Firefox in Troubleshoot Mode to check if one of the extensions ("3-bar" menu button or Tools -> Add-ons -> Extensions) or if hardware acceleration or userChrome.css is causing the problem.

• switch to the DEFAULT theme: "3-bar" menu button or Tools -> Add-ons -> Themes
• do NOT click the "Refresh Firefox" button on the Troubleshoot Mode start window

• https://support.mozilla.org/en-US/kb/diagnose-firefox-issues-using-troubleshoot-mode
• https://support.mozilla.org/en-US/kb/troubleshoot-extensions-themes-to-fix-problems

• https://support.mozilla.org/en-US/kb/enhanced-tracking-protection-firefox-desktop
• https://support.mozilla.org/en-US/kb/smartblock-enhanced-tracking-protection
• https://support.mozilla.org/en-US/kb/trackers-and-scripts-firefox-blocks-enhanced-track

Tried all and it does not work in Firefox. Works in Safari, Chrome etc. I am on a Mac - so no safe mode. Cleared cache - did nothing.

See How to use safe mode on your Mac - Apple Support

• https://support.apple.com/en-us/HT201262